PittsburghV1, Main, Exploration, bibRecord, 002F24

Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

Identifieur interne : 002F24 ( Main/Exploration ); précédent : 002F23; suivant : 002F25

Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

Auteurs : Tao Wu [République populaire de Chine, États-Unis] ; Holger Schwender [Allemagne] ; Ingo Ruczinski [États-Unis] ; Jeffrey C. Murray [États-Unis] ; Mary L. Marazita [États-Unis] ; Ronald G. Munger [États-Unis] ; Jacqueline B. Hetmanski [États-Unis] ; Margaret M. Parker [États-Unis] ; Ping Wang [République populaire de Chine] ; Tanda Murray [États-Unis] ; Margaret Taub [États-Unis] ; Shuai Li [République populaire de Chine] ; Richard J. Redett [États-Unis] ; M. Daniele Fallin [États-Unis] ; Kung Yee Liang [États-Unis, Taïwan] ; Yah Huei Wu-Chou [Taïwan] ; Samuel S. Chong [Singapour] ; Vincent Yeow [Singapour] ; Xiaoqian Ye [République populaire de Chine, États-Unis] ; Hong Wang [République populaire de Chine] ; Shangzhi Huang [République populaire de Chine] ; Ethylin W. Jabs [États-Unis] ; Bing Shi [République populaire de Chine] ; Allen J. Wilcox [États-Unis] ; Sun Ha Jee [Corée du Sud] ; Alan F. Scott [États-Unis] ; Terri H. Beaty [États-Unis]

Source :

PLoS ONE [ 1932-6203 ] ; 2014.

RBID : PMC:3916361

Descripteurs français

English descriptors

KwdEn :
- Asian Continental Ancestry Group (genetics), Chromosomes, Human, Pair 4 (genetics), Cleft Palate (genetics), Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Glucose Transport Proteins, Facilitative (genetics), Humans, Logistic Models, Male, Microfilament Proteins (genetics), Polymorphism, Single Nucleotide (genetics), Risk Factors, Tobacco Smoke Pollution (adverse effects).
MESH :
- chemical , adverse effects : Tobacco Smoke Pollution.
- chemical , genetics : Glucose Transport Proteins, Facilitative, Microfilament Proteins.
- genetics : Asian Continental Ancestry Group, Chromosomes, Human, Pair 4, Cleft Palate, Polymorphism, Single Nucleotide.
- Female, Gene-Environment Interaction, Genetic Predisposition to Disease, Humans, Logistic Models, Male, Risk Factors.

Abstract

Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures using conditional logistic regression models. While no single nucleotide polymorphism (SNP) achieved genome-wide significance when considered alone, markers in SLC2A9 and the neighboring WDR1 on chromosome 4p16.1 gave suggestive evidence of gene-environment interaction with environmental tobacco smoke (ETS) among 259 Asian trios when the models included a term for GxE interaction. Multiple SNPs in these two genes were associated with increased risk of nonsyndromic CP if the mother was exposed to ETS during the peri-conceptual period (3 months prior to conception through the first trimester). When maternal ETS was considered, fifteen of 135 SNPs mapping to SLC2A9 and 9 of 59 SNPs in WDR1 gave P values approaching genome-wide significance (10⁻⁶<P<10⁻⁴) in a test for GxETS interaction. SNPs rs3733585 and rs12508991 in SLC2A9 yielded P = 2.26×10⁻⁷ in a test for GxETS interaction. SNPs rs6820756 and rs7699512 in WDR1 also yielded P = 1.79×10⁻⁷ and P = 1.98×10⁻⁷ in a 1 df test for GxE interaction. Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest SLC2A9 and WDR1 should be considered as candidate genes for CP.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916361

DOI: 10.1371/journal.pone.0088088
PubMed: 24516586
PubMed Central: 3916361

Affiliations:

Le document en format XML

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</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mathematical Institute, Heinrich Heine University Duesseldorf, Duesseldorf</wicri:regionArea>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
<wicri:noRegion>Duesseldorf</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ruczinski, Ingo" sort="Ruczinski, Ingo" uniqKey="Ruczinski I" first="Ingo" last="Ruczinski">Ingo Ruczinski</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Murray, Jeffrey C" sort="Murray, Jeffrey C" uniqKey="Murray J" first="Jeffrey C." last="Murray">Jeffrey C. Murray</name>
<affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>University of Iowa, Children’s Hospital, Iowa City, Iowa, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Iowa, Children’s Hospital, Iowa City, Iowa</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Marazita, Mary L" sort="Marazita, Mary L" uniqKey="Marazita M" first="Mary L." last="Marazita">Mary L. Marazita</name>
<affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Munger, Ronald G" sort="Munger, Ronald G" uniqKey="Munger R" first="Ronald G." last="Munger">Ronald G. Munger</name>
<affiliation wicri:level="2"><nlm:aff id="aff6"><addr-line>Utah State University, Logan, Utah, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Utah State University, Logan, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hetmanski, Jacqueline B" sort="Hetmanski, Jacqueline B" uniqKey="Hetmanski J" first="Jacqueline B." last="Hetmanski">Jacqueline B. Hetmanski</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parker, Margaret M" sort="Parker, Margaret M" uniqKey="Parker M" first="Margaret M." last="Parker">Margaret M. Parker</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Ping" sort="Wang, Ping" uniqKey="Wang P" first="Ping" last="Wang">Ping Wang</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Peking University Health Science Center, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking University Health Science Center, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Murray, Tanda" sort="Murray, Tanda" uniqKey="Murray T" first="Tanda" last="Murray">Tanda Murray</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Taub, Margaret" sort="Taub, Margaret" uniqKey="Taub M" first="Margaret" last="Taub">Margaret Taub</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Shuai" sort="Li, Shuai" uniqKey="Li S" first="Shuai" last="Li">Shuai Li</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Peking University Health Science Center, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking University Health Science Center, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Redett, Richard J" sort="Redett, Richard J" uniqKey="Redett R" first="Richard J." last="Redett">Richard J. Redett</name>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fallin, M Daniele" sort="Fallin, M Daniele" uniqKey="Fallin M" first="M. Daniele" last="Fallin">M. Daniele Fallin</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liang, Kung Yee" sort="Liang, Kung Yee" uniqKey="Liang K" first="Kung Yee" last="Liang">Kung Yee Liang</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>National Yang-Ming University, Taipei, Taiwan</addr-line>
</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>National Yang-Ming University, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu Chou, Yah Huei" sort="Wu Chou, Yah Huei" uniqKey="Wu Chou Y" first="Yah Huei" last="Wu-Chou">Yah Huei Wu-Chou</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Chang Gung Memorial Hospital, Taoyuan, Taiwan</addr-line>
</nlm:aff>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Chang Gung Memorial Hospital, Taoyuan</wicri:regionArea>
<wicri:noRegion>Taoyuan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chong, Samuel S" sort="Chong, Samuel S" uniqKey="Chong S" first="Samuel S." last="Chong">Samuel S. Chong</name>
<affiliation wicri:level="4"><nlm:aff id="aff10"><addr-line>National University of Singapore, Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>National University of Singapore, Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author><name sortKey="Yeow, Vincent" sort="Yeow, Vincent" uniqKey="Yeow V" first="Vincent" last="Yeow">Vincent Yeow</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><addr-line>KK Women’s & Children’s Hospital, Singapore, Singapore</addr-line>
</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>KK Women’s & Children’s Hospital, Singapore</wicri:regionArea>
<wicri:noRegion>Singapore</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ye, Xiaoqian" sort="Ye, Xiaoqian" uniqKey="Ye X" first="Xiaoqian" last="Ye">Xiaoqian Ye</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><addr-line>Wuhan University, School of Stomatology, Wuhan, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Wuhan University, School of Stomatology, Wuhan</wicri:regionArea>
<wicri:noRegion>Wuhan</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Mount Sinai Medical Center, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mount Sinai Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Hong" sort="Wang, Hong" uniqKey="Wang H" first="Hong" last="Wang">Hong Wang</name>
<affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Peking University Health Science Center, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking University Health Science Center, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Shangzhi" sort="Huang, Shangzhi" uniqKey="Huang S" first="Shangzhi" last="Huang">Shangzhi Huang</name>
<affiliation wicri:level="3"><nlm:aff id="aff14"><addr-line>Peking Union Medical College, Beijing, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Peking Union Medical College, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jabs, Ethylin W" sort="Jabs, Ethylin W" uniqKey="Jabs E" first="Ethylin W." last="Jabs">Ethylin W. Jabs</name>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff13"><addr-line>Mount Sinai Medical Center, New York, New York, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Mount Sinai Medical Center, New York, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shi, Bing" sort="Shi, Bing" uniqKey="Shi B" first="Bing" last="Shi">Bing Shi</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><addr-line>State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Chengdu</wicri:regionArea>
<wicri:noRegion>Chengdu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wilcox, Allen J" sort="Wilcox, Allen J" uniqKey="Wilcox A" first="Allen J." last="Wilcox">Allen J. Wilcox</name>
<affiliation wicri:level="2"><nlm:aff id="aff16"><addr-line>NIEHS/NIH, Epidemiology Branch, Durham, North Carolina, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>NIEHS/NIH, Epidemiology Branch, Durham, North Carolina</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jee, Sun Ha" sort="Jee, Sun Ha" uniqKey="Jee S" first="Sun Ha" last="Jee">Sun Ha Jee</name>
<affiliation wicri:level="3"><nlm:aff id="aff17"><addr-line>Yonsei University, School of Public Health, Seoul, Korea</addr-line>
</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Yonsei University, School of Public Health, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scott, Alan F" sort="Scott, Alan F" uniqKey="Scott A" first="Alan F." last="Scott">Alan F. Scott</name>
<affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Johns Hopkins University, School of Medicine, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Medicine, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beaty, Terri H" sort="Beaty, Terri H" uniqKey="Beaty T" first="Terri H." last="Beaty">Terri H. Beaty</name>
<affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Johns Hopkins University, School of Public Health, Baltimore, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Johns Hopkins University, School of Public Health, Baltimore, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
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</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asian Continental Ancestry Group (genetics)</term>
<term>Chromosomes, Human, Pair 4 (genetics)</term>
<term>Cleft Palate (genetics)</term>
<term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Glucose Transport Proteins, Facilitative (genetics)</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Microfilament Proteins (genetics)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Risk Factors</term>
<term>Tobacco Smoke Pollution (adverse effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Chromosomes humains de la paire 4 (génétique)</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Fente palatine (génétique)</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Pollution par la fumée de tabac (effets indésirables)</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Population d'origine asiatique (génétique)</term>
<term>Protéines des microfilaments (génétique)</term>
<term>Prédisposition génétique à une maladie</term>
<term>Transporteurs de glucose par diffusion facilitée (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Tobacco Smoke Pollution</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucose Transport Proteins, Facilitative</term>
<term>Microfilament Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Pollution par la fumée de tabac</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asian Continental Ancestry Group</term>
<term>Chromosomes, Human, Pair 4</term>
<term>Cleft Palate</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chromosomes humains de la paire 4</term>
<term>Fente palatine</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine asiatique</term>
<term>Protéines des microfilaments</term>
<term>Transporteurs de glucose par diffusion facilitée</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Gene-Environment Interaction</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Interaction entre gènes et environnement</term>
<term>Modèles logistiques</term>
<term>Mâle</term>
<term>Prédisposition génétique à une maladie</term>
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<front><div type="abstract" xml:lang="en"><p>Nonsyndromic cleft palate (CP) is one of the most common human birth defects and both genetic and environmental risk factors contribute to its etiology. We conducted a genome-wide association study (GWAS) using 550 CP case-parent trios ascertained in an international consortium. Stratified analysis among trios with different ancestries was performed to test for GxE interactions with common maternal exposures using conditional logistic regression models. While no single nucleotide polymorphism (SNP) achieved genome-wide significance when considered alone, markers in <italic>SLC2A9</italic>
 and the neighboring <italic>WDR1</italic>
 on chromosome 4p16.1 gave suggestive evidence of gene-environment interaction with environmental tobacco smoke (ETS) among 259 Asian trios when the models included a term for GxE interaction. Multiple SNPs in these two genes were associated with increased risk of nonsyndromic CP if the mother was exposed to ETS during the peri-conceptual period (3 months prior to conception through the first trimester). When maternal ETS was considered, fifteen of 135 SNPs mapping to <italic>SLC2A9</italic>
 and 9 of 59 SNPs in <italic>WDR1</italic>
 gave <italic>P</italic>
 values approaching genome-wide significance (10<sup>−6</sup>
<<italic>P</italic>
<10<sup>−4</sup>
) in a test for GxETS interaction. SNPs rs3733585 and rs12508991 in <italic>SLC2A9</italic>
 yielded <italic>P</italic>
 = 2.26×10<sup>−7</sup>
 in a test for GxETS interaction. SNPs rs6820756 and rs7699512 in <italic>WDR1</italic>
 also yielded <italic>P</italic>
 = 1.79×10<sup>−7</sup>
 and <italic>P</italic>
 = 1.98×10<sup>−7</sup>
 in a 1 <italic>df</italic>
 test for GxE interaction. Although further replication studies are critical to confirming these findings, these results illustrate how genetic associations for nonsyndromic CP can be missed if potential GxE interaction is not taken into account, and this study suggest <italic>SLC2A9</italic>
 and <italic>WDR1</italic>
 should be considered as candidate genes for CP.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dixon, Mj" uniqKey="Dixon M">MJ Dixon</name>
</author>
<author><name sortKey="Marazita, Ml" uniqKey="Marazita M">ML Marazita</name>
</author>
<author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Murray, Jc" uniqKey="Murray J">JC Murray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tolarova, Mm" uniqKey="Tolarova M">MM Tolarová</name>
</author>
<author><name sortKey="Cervenka, J" uniqKey="Cervenka J">J Cervenka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grosen, D" uniqKey="Grosen D">D Grosen</name>
</author>
<author><name sortKey="Bille, C" uniqKey="Bille C">C Bille</name>
</author>
<author><name sortKey="Petersen, I" uniqKey="Petersen I">I Petersen</name>
</author>
<author><name sortKey="Skytthe, A" uniqKey="Skytthe A">A Skytthe</name>
</author>
<author><name sortKey="Hjelmborg, Jv" uniqKey="Hjelmborg J">Jv Hjelmborg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moreno, Lm" uniqKey="Moreno L">LM Moreno</name>
</author>
<author><name sortKey="Mansilla, Ma" uniqKey="Mansilla M">MA Mansilla</name>
</author>
<author><name sortKey="Bullard, Sa" uniqKey="Bullard S">SA Bullard</name>
</author>
<author><name sortKey="Cooper, Me" uniqKey="Cooper M">ME Cooper</name>
</author>
<author><name sortKey="Busch, Td" uniqKey="Busch T">TD Busch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jugessur, A" uniqKey="Jugessur A">A Jugessur</name>
</author>
<author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name>
</author>
<author><name sortKey="Gjessing, Hk" uniqKey="Gjessing H">HK Gjessing</name>
</author>
<author><name sortKey="Lie, Rt" uniqKey="Lie R">RT Lie</name>
</author>
<author><name sortKey="Wilcox, Aj" uniqKey="Wilcox A">AJ Wilcox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Carter, Tc" uniqKey="Carter T">TC Carter</name>
</author>
<author><name sortKey="Molloy, Am" uniqKey="Molloy A">AM Molloy</name>
</author>
<author><name sortKey="Pangilinan, F" uniqKey="Pangilinan F">F Pangilinan</name>
</author>
<author><name sortKey="Troendle, Jf" uniqKey="Troendle J">JF Troendle</name>
</author>
<author><name sortKey="Kirke, Pn" uniqKey="Kirke P">PN Kirke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Birnbaum, S" uniqKey="Birnbaum S">S Birnbaum</name>
</author>
<author><name sortKey="Ludwig, Ku" uniqKey="Ludwig K">KU Ludwig</name>
</author>
<author><name sortKey="Reutter, H" uniqKey="Reutter H">H Reutter</name>
</author>
<author><name sortKey="Herms, S" uniqKey="Herms S">S Herms</name>
</author>
<author><name sortKey="Steffens, M" uniqKey="Steffens M">M Steffens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grant, Sf" uniqKey="Grant S">SF Grant</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
</author>
<author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Glaberson, W" uniqKey="Glaberson W">W Glaberson</name>
</author>
<author><name sortKey="Annaiah, K" uniqKey="Annaiah K">K Annaiah</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mangold, E" uniqKey="Mangold E">E Mangold</name>
</author>
<author><name sortKey="Ludwig, Ku" uniqKey="Ludwig K">KU Ludwig</name>
</author>
<author><name sortKey="Birnbaum, S" uniqKey="Birnbaum S">S Birnbaum</name>
</author>
<author><name sortKey="Baluardo, C" uniqKey="Baluardo C">C Baluardo</name>
</author>
<author><name sortKey="Ferrian, M" uniqKey="Ferrian M">M Ferrian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Murray, Jc" uniqKey="Murray J">JC Murray</name>
</author>
<author><name sortKey="Marazita, Ml" uniqKey="Marazita M">ML Marazita</name>
</author>
<author><name sortKey="Munger, Rg" uniqKey="Munger R">RG Munger</name>
</author>
<author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ludwig, Ku" uniqKey="Ludwig K">KU Ludwig</name>
</author>
<author><name sortKey="Mangold, E" uniqKey="Mangold E">E Mangold</name>
</author>
<author><name sortKey="Herms, S" uniqKey="Herms S">S Herms</name>
</author>
<author><name sortKey="Nowak, S" uniqKey="Nowak S">S Nowak</name>
</author>
<author><name sortKey="Reutter, H" uniqKey="Reutter H">H Reutter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hwang, Sj" uniqKey="Hwang S">SJ Hwang</name>
</author>
<author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Panny, Sr" uniqKey="Panny S">SR Panny</name>
</author>
<author><name sortKey="Street, Na" uniqKey="Street N">NA Street</name>
</author>
<author><name sortKey="Joseph, Jm" uniqKey="Joseph J">JM Joseph</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maestri, Ne" uniqKey="Maestri N">NE Maestri</name>
</author>
<author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Hetmanski, J" uniqKey="Hetmanski J">J Hetmanski</name>
</author>
<author><name sortKey="Smith, Ea" uniqKey="Smith E">EA Smith</name>
</author>
<author><name sortKey="Mcintosh, I" uniqKey="Mcintosh I">I McIntosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name>
</author>
<author><name sortKey="Christensen, K" uniqKey="Christensen K">K Christensen</name>
</author>
<author><name sortKey="Weinberg, Cr" uniqKey="Weinberg C">CR Weinberg</name>
</author>
<author><name sortKey="Romitti, P" uniqKey="Romitti P">P Romitti</name>
</author>
<author><name sortKey="Bathum, L" uniqKey="Bathum L">L Bathum</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chevrier, C" uniqKey="Chevrier C">C Chevrier</name>
</author>
<author><name sortKey="Bahuau, M" uniqKey="Bahuau M">M Bahuau</name>
</author>
<author><name sortKey="Perret, C" uniqKey="Perret C">C Perret</name>
</author>
<author><name sortKey="Iovannisci, Dm" uniqKey="Iovannisci D">DM Iovannisci</name>
</author>
<author><name sortKey="Nelva, A" uniqKey="Nelva A">A Nelva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Den Boogaard, Mj" uniqKey="Van Den Boogaard M">MJ van den Boogaard</name>
</author>
<author><name sortKey="De Costa, D" uniqKey="De Costa D">D de Costa</name>
</author>
<author><name sortKey="Krapels, Ip" uniqKey="Krapels I">IP Krapels</name>
</author>
<author><name sortKey="Liu, F" uniqKey="Liu F">F Liu</name>
</author>
<author><name sortKey="Van Duijn, C" uniqKey="Van Duijn C">C van Duijn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jianyan, L" uniqKey="Jianyan L">L Jianyan</name>
</author>
<author><name sortKey="Zeqiang, G" uniqKey="Zeqiang G">G Zeqiang</name>
</author>
<author><name sortKey="Yongjuan, C" uniqKey="Yongjuan C">C Yongjuan</name>
</author>
<author><name sortKey="Kaihong, D" uniqKey="Kaihong D">D Kaihong</name>
</author>
<author><name sortKey="Bing, D" uniqKey="Bing D">D Bing</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Zhu, Gq" uniqKey="Zhu G">GQ Zhu</name>
</author>
<author><name sortKey="Meng, T" uniqKey="Meng T">T Meng</name>
</author>
<author><name sortKey="Shi, Jy" uniqKey="Shi J">JY Shi</name>
</author>
<author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name>
</author>
<author><name sortKey="Fallin, Md" uniqKey="Fallin M">MD Fallin</name>
</author>
<author><name sortKey="Shi, M" uniqKey="Shi M">M Shi</name>
</author>
<author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name>
</author>
<author><name sortKey="Liang, Ky" uniqKey="Liang K">KY Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jia, Zl" uniqKey="Jia Z">ZL Jia</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Chen, Ch" uniqKey="Chen C">CH Chen</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeiger, Js" uniqKey="Zeiger J">JS Zeiger</name>
</author>
<author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Liang, Ky" uniqKey="Liang K">KY Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name>
</author>
<author><name sortKey="Murray, Jc" uniqKey="Murray J">JC Murray</name>
</author>
<author><name sortKey="Marazita, Ml" uniqKey="Marazita M">ML Marazita</name>
</author>
<author><name sortKey="Munger, Rg" uniqKey="Munger R">RG Munger</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Schwender, H" uniqKey="Schwender H">H Schwender</name>
</author>
<author><name sortKey="Taub, Ma" uniqKey="Taub M">MA Taub</name>
</author>
<author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Marazita, Ml" uniqKey="Marazita M">ML Marazita</name>
</author>
<author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Spielman, Rs" uniqKey="Spielman R">RS Spielman</name>
</author>
<author><name sortKey="Mcginnis, Re" uniqKey="Mcginnis R">RE McGinnis</name>
</author>
<author><name sortKey="Ewens, Wj" uniqKey="Ewens W">WJ Ewens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Laurie, Cc" uniqKey="Laurie C">CC Laurie</name>
</author>
<author><name sortKey="Doheny, Kf" uniqKey="Doheny K">KF Doheny</name>
</author>
<author><name sortKey="Mirel, Db" uniqKey="Mirel D">DB Mirel</name>
</author>
<author><name sortKey="Pugh, Ew" uniqKey="Pugh E">EW Pugh</name>
</author>
<author><name sortKey="Bierut, Lj" uniqKey="Bierut L">LJ Bierut</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Howie, B" uniqKey="Howie B">B Howie</name>
</author>
<author><name sortKey="Donnelly, P" uniqKey="Donnelly P">P Donnelly</name>
</author>
<author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Little, J" uniqKey="Little J">J Little</name>
</author>
<author><name sortKey="Cardy, A" uniqKey="Cardy A">A Cardy</name>
</author>
<author><name sortKey="Munger, Rg" uniqKey="Munger R">RG Munger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Honein, Ma" uniqKey="Honein M">MA Honein</name>
</author>
<author><name sortKey="Rasmussen, Sa" uniqKey="Rasmussen S">SA Rasmussen</name>
</author>
<author><name sortKey="Reefhuis, J" uniqKey="Reefhuis J">J Reefhuis</name>
</author>
<author><name sortKey="Romitti, Pa" uniqKey="Romitti P">PA Romitti</name>
</author>
<author><name sortKey="Lammer, Ej" uniqKey="Lammer E">EJ Lammer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romitti, Pa" uniqKey="Romitti P">PA Romitti</name>
</author>
<author><name sortKey="Lidral, Ac" uniqKey="Lidral A">AC Lidral</name>
</author>
<author><name sortKey="Munger, Rg" uniqKey="Munger R">RG Munger</name>
</author>
<author><name sortKey="Daack Hirsch, S" uniqKey="Daack Hirsch S">S Daack-Hirsch</name>
</author>
<author><name sortKey="Burns, Tl" uniqKey="Burns T">TL Burns</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaty, Th" uniqKey="Beaty T">TH Beaty</name>
</author>
<author><name sortKey="Hetmanski, Jb" uniqKey="Hetmanski J">JB Hetmanski</name>
</author>
<author><name sortKey="Zeiger, Js" uniqKey="Zeiger J">JS Zeiger</name>
</author>
<author><name sortKey="Fan, Yt" uniqKey="Fan Y">YT Fan</name>
</author>
<author><name sortKey="Liang, Ky" uniqKey="Liang K">KY Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ingersoll, Rg" uniqKey="Ingersoll R">RG Ingersoll</name>
</author>
<author><name sortKey="Hetmanski, J" uniqKey="Hetmanski J">J Hetmanski</name>
</author>
<author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name>
</author>
<author><name sortKey="Fallin, Md" uniqKey="Fallin M">MD Fallin</name>
</author>
<author><name sortKey="Mcintosh, I" uniqKey="Mcintosh I">I McIntosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name>
</author>
<author><name sortKey="Liang, Ky" uniqKey="Liang K">KY Liang</name>
</author>
<author><name sortKey="Hetmanski, Jb" uniqKey="Hetmanski J">JB Hetmanski</name>
</author>
<author><name sortKey="Ruczinski, I" uniqKey="Ruczinski I">I Ruczinski</name>
</author>
<author><name sortKey="Fallin, Md" uniqKey="Fallin M">MD Fallin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kato, A" uniqKey="Kato A">A Kato</name>
</author>
<author><name sortKey="Kurita, S" uniqKey="Kurita S">S Kurita</name>
</author>
<author><name sortKey="Hayashi, A" uniqKey="Hayashi A">A Hayashi</name>
</author>
<author><name sortKey="Kaji, N" uniqKey="Kaji N">N Kaji</name>
</author>
<author><name sortKey="Ohashi, K" uniqKey="Ohashi K">K Ohashi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gearing, M" uniqKey="Gearing M">M Gearing</name>
</author>
<author><name sortKey="Juncos, Jl" uniqKey="Juncos J">JL Juncos</name>
</author>
<author><name sortKey="Procaccio, V" uniqKey="Procaccio V">V Procaccio</name>
</author>
<author><name sortKey="Gutekunst, Ca" uniqKey="Gutekunst C">CA Gutekunst</name>
</author>
<author><name sortKey="Marino Rodriguez, Em" uniqKey="Marino Rodriguez E">EM Marino-Rodriguez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doring, A" uniqKey="Doring A">A Döring</name>
</author>
<author><name sortKey="Gieger, C" uniqKey="Gieger C">C Gieger</name>
</author>
<author><name sortKey="Mehta, D" uniqKey="Mehta D">D Mehta</name>
</author>
<author><name sortKey="Gohlke, H" uniqKey="Gohlke H">H Gohlke</name>
</author>
<author><name sortKey="Prokisch, H" uniqKey="Prokisch H">H Prokisch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vitart, V" uniqKey="Vitart V">V Vitart</name>
</author>
<author><name sortKey="Rudan, I" uniqKey="Rudan I">I Rudan</name>
</author>
<author><name sortKey="Hayward, C" uniqKey="Hayward C">C Hayward</name>
</author>
<author><name sortKey="Gray, Nk" uniqKey="Gray N">NK Gray</name>
</author>
<author><name sortKey="Floyd, J" uniqKey="Floyd J">J Floyd</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcardle, Pf" uniqKey="Mcardle P">PF McArdle</name>
</author>
<author><name sortKey="Parsa, A" uniqKey="Parsa A">A Parsa</name>
</author>
<author><name sortKey="Chang, Yp" uniqKey="Chang Y">YP Chang</name>
</author>
<author><name sortKey="Weir, Mr" uniqKey="Weir M">MR Weir</name>
</author>
<author><name sortKey="O Onnell, Jr" uniqKey="O Onnell J">JR O’Connell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dehghan, A" uniqKey="Dehghan A">A Dehghan</name>
</author>
<author><name sortKey="Kottgen, A" uniqKey="Kottgen A">A Köttgen</name>
</author>
<author><name sortKey="Yang, Q" uniqKey="Yang Q">Q Yang</name>
</author>
<author><name sortKey="Hwang, Sj" uniqKey="Hwang S">SJ Hwang</name>
</author>
<author><name sortKey="Kao, Wl" uniqKey="Kao W">WL Kao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kolz, M" uniqKey="Kolz M">M Kolz</name>
</author>
<author><name sortKey="Johnson, T" uniqKey="Johnson T">T Johnson</name>
</author>
<author><name sortKey="Sanna, S" uniqKey="Sanna S">S Sanna</name>
</author>
<author><name sortKey="Teumer, A" uniqKey="Teumer A">A Teumer</name>
</author>
<author><name sortKey="Vitart, V" uniqKey="Vitart V">V Vitart</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Q" uniqKey="Yang Q">Q Yang</name>
</author>
<author><name sortKey="Kottgen, A" uniqKey="Kottgen A">A Köttgen</name>
</author>
<author><name sortKey="Dehghan, A" uniqKey="Dehghan A">A Dehghan</name>
</author>
<author><name sortKey="Smith, Av" uniqKey="Smith A">AV Smith</name>
</author>
<author><name sortKey="Glazer, Nl" uniqKey="Glazer N">NL Glazer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Charles, Ba" uniqKey="Charles B">BA Charles</name>
</author>
<author><name sortKey="Shriner, D" uniqKey="Shriner D">D Shriner</name>
</author>
<author><name sortKey="Doumatey, A" uniqKey="Doumatey A">A Doumatey</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Chu, N" uniqKey="Chu N">N Chu</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Luan, J" uniqKey="Luan J">J Luan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weinberg, Cr" uniqKey="Weinberg C">CR Weinberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gu, D" uniqKey="Gu D">D Gu</name>
</author>
<author><name sortKey="Wu, X" uniqKey="Wu X">X Wu</name>
</author>
<author><name sortKey="Reynolds, K" uniqKey="Reynolds K">K Reynolds</name>
</author>
<author><name sortKey="Duan, X" uniqKey="Duan X">X Duan</name>
</author>
<author><name sortKey="Xin, X" uniqKey="Xin X">X Xin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cordell, Hj" uniqKey="Cordell H">HJ Cordell</name>
</author>
<author><name sortKey="Barratt, Bj" uniqKey="Barratt B">BJ Barratt</name>
</author>
<author><name sortKey="Clayton, Dg" uniqKey="Clayton D">DG Clayton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Starr, Jr" uniqKey="Starr J">JR Starr</name>
</author>
<author><name sortKey="Hsu, L" uniqKey="Hsu L">L Hsu</name>
</author>
<author><name sortKey="Schwartz, Sm" uniqKey="Schwartz S">SM Schwartz</name>
</author>
</analytic>
</biblStruct>
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   |wiki=    Wicri/Amérique
   |area=    PittsburghV1
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   |type=    RBID
   |clé=     PMC:3916361
   |texte=   Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate
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Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

Evidence of Gene−Environment Interaction for Two Genes on Chromosome 4 and Environmental Tobacco Smoke in Controlling the Risk of Nonsyndromic Cleft Palate

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